Early BAMI stands for: Early Beta blocker Administration before reperfusion in patients with ST-Elevation Myocardial Infarction who are planned to undergo primary PCI

The trial evaluated the beneficial effects of early administration of 5 mg intravenous Metoprolol or placebo before reperfusion in the ambulance or emergency room in patients with ST elevation myocardial infarction. The physician-initiated, prospective, multicenter, randomized, double-blind, placebo controlled trial has now completed enrollment and follow up till two years of all 684 patients in 14 centers in The Netherlands and Spain.

The primary endpoint is infarct size as measured by cardiac MRI 1 month post-MI. Patients have been randomized in a 1:1 fashion to receive either Metoprolol or placebo.

Principal investigator is Vincent Roolvink MD of the Isala hospital, Zwolle, The Netherlands. Coordinating investigator of Spain is Borja Ibañez MD, PhD of CNIC and Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. Patients were mainly included in the acute phase by ambulance services:

The Netherlands:

Spain: SUMMA 112

The first patient was included in the Isala hospital in The Netherlands in May 2012. 

Clinical trial information:


Main publications:

  • Roolvink V, Ottervanger JP, Ibáñez B et al. One year clinical outcome of early administration of intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary reperfusion. One year results from the EARLY-BAMI trial. EuroIntervention. 2017 Nov 21.
  • Roolvink V, Ibañez B, Ottervanger JP et al. Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention. JACC 2016;67:2705-15.
  • Roolvink V, Rasoul S, Ottervanger JP et al. Rationale and design of a double-blind, multicenter, randomized, placebo-controlled clinical trial of early administration of intravenous β-blockers in patients with ST-elevation myocardial infarction before primary percutaneous coronary intervention: EARLY β-blocker Administration before primary PCI in patients with ST-elevation Myocardial Infarction trial. Am Heart J 2014;168:661-6.